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The bacteria create havoc in the body. The immune system goes into overdrive. The heightened immune response can lead to sepsis, which kills 30 to 50 per cent of the people who develop it. Using a process that allows scientists to see what’s happening inside living animals, called intravital microscopy, researchers discovered that the toxin causes platelets to respond abnormally in mice.
Platelets’ primary role is to help stop bleeding in mammals after injury. Surewaard, Ajitha Thanabalasuriar, Zhutian Zheng, Christine Tkaczyk, Taylor S. Jorch, Carsten Deppermann, Juliane Bubeck Wardenburg, Rachelle P. Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. Researchers at the Stanford University School of Medicine have identified a molecule that serves as natural protection against one of the most common intestinal pathogens. Propionate, a byproduct of metabolism by a group of bacteria called the Bacteroides, inhibits the growth of Salmonella in the intestinal tract of mice, according to the researchers. The researchers determined that propionate doesn’t trigger the immune response to thwart the pathogen.
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